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In pharmacological science, the end of the XX century was marked by a phenomenal breakthrough in the treatment of male impotence. It was then that sildenafil citrate was discovered, a substance that is now marketed under the universally recognizable brand name of Viagra. Apart from the brand pills, sildenafil citrate is available as Generic Viagra solution which is much more accessible for people with moderate income. Sildenafil, which makes the base for both brand and Generic Viagra, is a member of PDE5 inhibitors family.

The point in blocking PDE5 phosphodiesterase type 5 is that this enzyme promotes rigidity of blood vessels, whereas achieving erection requires elasticity of blood vessel walls.

There have been developed three inhibitors of PDE5 enzyme so far, all of them used for addressing erectile problems. They are, mentioned in chronological order of their appearance, Viagra, Levitra and Cialis. Although those drugs have very similar mechanism resulting from their belonging to one and the same class of drugs, Viagra, Levitra and Cialis have some major differences when it comes down to nuances.

Cialis stands out since it is much longer-acting than both Viagra and Levitra, and it is compatible with alcohol. Levitra has fewest adverse effects as compared to Viagra and Cialis. We have already brushed upon the main medicinal component of Viagra, sildenafil citrate.

The formula for the molecule was discovered in Citrate of sildenafil was a result of researches aimed at discovering a drug against PAH pulmonary arterial hypertension.

Sildenafil filled in the bill just fine, but a very pronounced benign side effects to its main action was discovered, and that was a multifold increase in erectile intensity.

The original developer focused on this side event, and several years later the diamond-shaped pill which we now know as Viagra hit the market. It was destined to become an enormous success and a fast favorite with doctors and patients. Having no competition in the industry, sildenafil citrate continued its glorified conquering march through the pharmacies of the world.

Sildenafil citrate is the heart and soul of Viagra. In fact, sildenafil citrate is Viagra, and hence the two terms are interchangeable in pharmacology. When writing a prescription, your doctor might refer to the drug either as Viagra or sildenafil citrate.

This is a key point in understanding what Generic Viagra is, since the present article will deal with this later. From the point of view of its pharmacological class, sildenafil is an inhibitor of phosphodiesterase type 5 and thus a powerful vasodilator. These qualities of sildenafil citrate condition its application in ED treatment. Read on to learn about the mechanisms of the substance. We have already established that sildenafil citrate acts by inhibiting phosphodiesterase type 5, or simply PDE5.

PDE5 is a blood vessel-calcifying agent that in healthy individuals is produced to help return the penis to its flaccid state. In ED-affected men PDE5 plays a morbific role, preventing erection from happening, in part or in full. When sildenafil citrate blocks excessive production of PDE5, it promotes release of substance called cyclic guanosine monophosphate cGMP , which is responsible for relaxing smooth muscle tissues. Blood vessels become less rigid and more elastic, they expand and absorb blood which is necessary for developing a stable and hard erection that lasts for as long as it is required to satisfy both partners.

Sildenafil citrate is absorbed into the blood flow on average within 60 minutes after a pill of Viagra is taken. Its action then continues during approximately 4 hours, but these estimations are relative and depend on a number of factors, such as the time, quantity and quality of meals consumed prior to sildenafil taking, individual body response, severity of condition, etc. Sildenafil citrate is a drug that is well-tested both in vitro and in vivo.

Its history goes almost two decades back, so it is safe to say that its long-term effects are thoroughly studied. It is nevertheless critical to learn about safety of Viagra use before proceeding to taking the drug.

This is a regular practice for each prescription and over-the-counter drug that there is. It mostly concerns contraindications, compatibility with other drugs, possible side effects and dosage instructions.

While dosing will be viewed in a separate paragraph, other essential safety information about Generic Viagra is given in the table below. It is recommended to avoid drinking alcohol while taking Generic Viagra. Ingesting meals with high fat content can delay effects of sildenafil citrate, which are manifested best when the drug is taken in a fasted state.

A light meal will minimize side effects. Consuming grapefruit will delay the onset of Viagra effects and make them less pronounced. Please observe that this information is incomplete. You should consult your practitioner and ask for full information regarding the above before you buy Generic Viagra and proceed with the therapy. Generic Viagra is a full analogue of brand Viagra, which means that it replicates the list of brand drug ingredient in every detail.

Before you take your first dose of Generic Viagra, make sure that you are not allergic towards any ingredient on the following list:. The biggest factor that sets Generic Viagra pills apart from its brand equivalent is its price.

In every other aspect and each minute detail, Generic Viagra is the same as its way more expensive brand counterpart. Generic Viagra is manufactured by pharmaceuticals that are different than the original developer. Becoming a generic version of its brand analogue is a milestone in life of every drug.

This happens when the laboratory who was the first to discover the drug and its benefits no longer holds the patent. Drugs produced by non-developer companies are considerably cheaper, which is explained by the absence of necessity to invest in researches, testing, patenting, promoting, etc.

Brand drugs very infrequently become cheaper after generics hit the market; they have to maintain high cost for the drugs they produce in order to be able to sustain the ongoing researches and developing new drugs. Generic sildenafil citrate pills are as efficient as reliable as brand Viagra tablets. The pills of Generic Viagra are formulated to be equivalent to sildenafil 25 mg, sildenafil 50 mg and sildenafil mg, though there are a few Generic Viagra types that go beyond that and exceed the maximal dose of brand Viagra sildenafil mg all the way up to sildenafil mg.

The pills with elevated content of sildenafil should be taken with caution and under a close supervision on the side of the healthcare provider. Establishing the minimal efficient and the maximal allowed dose of Generic Viagra is done by the doctor at all times.

The correct dose will be appointed to you based on results yielded by a number of laboratory test and physical examination. It can be a subject to adjustment upon follow-ups. Never change your dose unless approved by the prescriber. One should start with the lowest dose of Generic Viagra, sildenafil 25 mg. The step is increased by another 25 mg to sildenafil 50 mg, if approved by the practitioner and is seen as needed by them.

Most of men aged between 40 and 60 find the dose of Generic Viagra 50 mg beneficial. Maximal doses of sildenafil citrate should be avoided by patients with comorbidities or after the age of Double doses of Generic Viagra should never be taken.

Generic Viagra is available in three different doses of the active substance sildenafil: If you have any type of underlying health problems or if you are older and more sensitive to side effects, you should definitely start with generic Viagra 25 mg. However, there is no reason why you should not start with the lowest dose even if you do not have health problems because the risk is lower for side effects and it is individual how much dose of sildenafil each person needs to notice an effect.

Healthy and strong individuals often start with generic Viagra 50mg, which is the so-called starting dose. Once you have taken this dose, you should know yourself — you have experienced the desired effect and have experienced side effects. However, if you experienced 50 mg side effects, you can reduce the dose to 25 mg instead. This way you can easily reach the perfect dose for each individual. If you do not experience enough effect with the intermediate dose, you can try generic Viagra mg instead.

It should be borne in mind that increasing the dose to mg dosage increases the risk of side effects. Therefore, you should always consult a doctor before increasing the dose. By inhibiting PDE5 enzyme and thus bringing on release of cGMP, sildenafil citrate helps smooth muscles to relax and the walls of blood vessels expand. This spurs up the blood flow pace and increases the capacity of blood vessels. The spongeous bodies found on both sides of the urethra get filled up with blood which is trapped within them until erection subsides after ejaculation.

Thus the natural mechanism of erection is reconstructed in every detail. Sildenafil citrate begins producing its benefits within 60 minutes after the intake, and it continues to be effective during 4 more hours.

Man can achieve several erections as desired while Generic Viagra effects go on. The time needed for erectile recovery is minimized in patients taking Generic Viagra. Remember that Generic Viagra is not an aphrodisiac, and it will not augment your sexual appetite.

While your libido will stay the same, your ability to act up to your sexual desire will be optimized. Generic Viagra is not a contraceptive and it cannot be used as STDs protection. Generic Viagra is designed for oral administration.

Take one pill in the dosage appointed to you by your prescriber. Wash it down by a glass of water. Chewing, breaking and crushing the pill in the mouth is not recommended. Allow for approximately 60 minutes to pass for sildenafil effects to set in. This time will decrease as you go on with Generic Viagra therapy. The body response will also improve as the therapy continues. Do not take more than one recommended dose during the period of 24 hours.

For maximal effects, do not drink alcohol while taking Generic Viagra. A light meal will decrease risks for side events. Fatty foods will delay the onset of sildenafil effects and compromise their intensity. Take a tablet of water. It is quite good to take the tablet in conjunction with food, but keep in mind that if you eat a lot, especially high fat foods, it may take longer before the active substance sildenafil is taken up in the bloodstream.

One tablet can be taken per day according to the recommended dose and under no circumstances should you overdose. The abuse of addictive substances such as tobacco, alcohol, or drugs can decrease sexual abilities.

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