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Shelf life for viagra

Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www. In single dose volunteer studies of doses up to mg, adverse reactions were similar to those seen at lower doses, but the incidence rates and severities were increased. Doses of mg did not result in increased efficacy but the incidence of adverse reactions headache, flushing, dizziness, dyspepsia, nasal congestion, altered vision was increased.

In cases of overdose, standard supportive measures should be adopted as required. Renal dialysis is not expected to accelerate clearance as sildenafil is highly bound to plasma proteins and not eliminated in the urine.

Sildenafil is an oral therapy for erectile dysfunction. In the natural setting, i. The physiological mechanism responsible for erection of the penis involves the release of nitric oxide NO in the corpus cavernosum during sexual stimulation.

Nitric oxide then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate cGMP , producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. Sildenafil has a peripheral site of action on erections.

Sildenafil has no direct relaxant effect on isolated human corpus cavernosum but potently enhances the relaxant effect of NO on this tissue. Therefore sexual stimulation is required in order for sildenafil to produce its intended beneficial pharmacological effects.

Studies in vitro have shown that sildenafil is selective for PDE5, which is involved in the erection process.

Its effect is more potent on PDE5 than on other known phosphodiesterases. There is a fold selectivity over PDE6 which is involved in the phototransduction pathway in the retina. At maximum recommended doses, there is an fold selectivity over PDE1, and over fold over PDE 2, 3, 4, 7, 8, 9, 10 and In particular, sildenafil has greater than 4,fold selectivity for PDE5 over PDE3, the cAMP-specific phosphodiesterase isoform involved in the control of cardiac contractility.

Two clinical studies were specifically designed to assess the time window after dosing during which sildenafil could produce an erection in response to sexual stimulation. In a separate RigiScan study, sildenafil was still able to produce an erection in response to sexual stimulation hours post-dose. Sildenafil causes mild and transient decreases in blood pressure which, in the majority of cases, do not translate into clinical effects.

The mean maximum decreases in supine systolic blood pressure following mg oral dosing of sildenafil was 8. The corresponding change in supine diastolic blood pressure was 5. These decreases in blood pressure are consistent with the vasodilatory effects of sildenafil, probably due to increased cGMP levels in vascular smooth muscle.

Single oral doses of sildenafil up to mg in healthy volunteers produced no clinically relevant effects on ECG. Sildenafil showed no effect on cardiac output, and did not impair blood flow through the stenosed coronary arteries. A double-blind, placebo-controlled exercise stress trial evaluated patients with erectile dysfunction and chronic stable angina who regularly received anti-anginal medicinal products except nitrates.

The results demonstrated no clinically relevant differences between sildenafil and placebo in time to limiting angina. The postulated mechanism for this change in colour discrimination is related to inhibition of PDE6, which is involved in the phototransduction cascade of the retina. Sildenafil has no effect on visual acuity or contrast sensitivity. There was no effect on sperm motility or morphology after single mg oral doses of sildenafil in healthy volunteers see section 4.

In clinical trials sildenafil was administered to more than patients aged The following patient groups were represented: The following groups were not well represented or excluded from clinical trials: In controlled clinical trials, the discontinuation rate due to sildenafil was low and similar to placebo.

Across all trials, the proportion of patients reporting improvement on sildenafil were as follows: The safety and efficacy of sildenafil was maintained in long term studies. The European Medicines Agency has waived the obligation to submit the results of studies with VIAGRA in all subsets of the paediatric population for the treatment of erectile dysfunction.

Sildenafil is rapidly absorbed. Maximum observed plasma concentrations are reached within 30 to minutes median 60 minutes of oral dosing in the fasted state. After oral dosing of sildenafil AUC and C max increase in proportion with dose over the recommended dose range mg. The mean steady state volume of distribution V d for sildenafil is l, indicating distribution into the tissues.

Protein binding is independent of total drug concentrations. In healthy volunteers receiving sildenafil mg single dose , less than 0. The major circulating metabolite results from N-demethylation of sildenafil.

The N-desmethyl metabolite is further metabolised, with a terminal half life of approximately 4 h. However, due to high inter-subject variability, these differences were not statistically significant.

The pharmacokinetics of sildenafil in patients with severely impaired hepatic function have not been studied. Non-clinical data revealed no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential, and toxicity to reproduction and development.

Detailed information on this medicinal product is available on the website of the European Medicines Agency http: This site uses cookies. By continuing to browse the site you are agreeing to our policy on the use of cookies. Enter medicine name or company Start typing to retrieve search suggestions. Continue typing to refine. Viagra 25mg, 50mg, mg. Back to top Pfizer Limited contact details. Active ingredient sildenafil citrate. Last updated on eMC: Show table of contents Hide table of contents 1.

Name of the medicinal product 2. Qualitative and quantitative composition 3. Marketing authorisation holder 8. Marketing authorisation number s 9.

Date of revision of the text. This information is intended for use by health professionals. Each tablet contains sildenafil citrate equivalent to 25, 50 or mg of sildenafil. Excipient with known effect: For the full list of excipients, see section 6. Posology Use in adults The recommended dose is 50 mg taken as needed approximately one hour before sexual activity.

Hepatic impairment Since sildenafil clearance is reduced in patients with hepatic impairment e. Use in patients taking other medicinal products With the exception of ritonavir for which co-administration with sildenafil is not advised see Section 4. Method of administration For oral use.

Hypersensitivity to the active substance or to any of the excipients listed in section 6. Cardiovascular risk factors Prior to initiating any treatment for erectile dysfunction, physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity.

Priapism Agents for the treatment of erectile dysfunction, including sildenafil, should be used with caution in patients with anatomical deformation of the penis such as angulation, cavernosal fibrosis or Peyronie's disease , or in patients who have conditions which may predispose them to priapism such as sickle cell anaemia, multiple myeloma or leukaemia.

Concomitant use with other PDE5 inhibitors or other treatments for erectile dysfunction The safety and efficacy of combinations of sildenafil with other PDE5 inhibitors, or other pulmonary arterial hypertension PAH treatments containing sildenafil REVATIO , or other treatments for erectile dysfunction have not been studied. Effects on vision Cases of visual defects have been reported spontaneously in connection with the intake of sildenafil and other PDE5 inhibitors see section 4.

Concomitant use with ritonavir Co-administration of sildenafil with ritonavir is not advised see section 4. Concomitant use with alpha-blockers Caution is advised when sildenafil is administered to patients taking an alpha-blocker, as the co-administration may lead to symptomatic hypotension in a few susceptible individuals see section 4.

Effect on bleeding Studies with human platelets indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside in vitro. Effects of other medicinal products on sildenafil In vitro studies Sildenafil metabolism is principally mediated by the cytochrome P CYP isoforms 3A4 major route and 2C9 minor route. In vivo studies Population pharmacokinetic analysis of clinical trial data indicated a reduction in sildenafil clearance when co-administered with CYP3A4 inhibitors such as ketoconazole, erythromycin, cimetidine.

There are no adequate and well-controlled studies in pregnant or breast-feeding women. Viagra may have a minor influence on the ability to drive and use machines. Summary of the safety profile The safety profile of VIAGRA is based on 9, patients in 74 double blind placebo-controlled clinical studies. Urologicals; Drugs used in erectile dysfunction. Mechanism of action Sildenafil is an oral therapy for erectile dysfunction.

Pharmacodynamic effects Studies in vitro have shown that sildenafil is selective for PDE5, which is involved in the erection process. Clinical efficacy and safety Two clinical studies were specifically designed to assess the time window after dosing during which sildenafil could produce an erection in response to sexual stimulation.

Further information on clinical trials In clinical trials sildenafil was administered to more than patients aged Paediatric population The European Medicines Agency has waived the obligation to submit the results of studies with VIAGRA in all subsets of the paediatric population for the treatment of erectile dysfunction.

Absorption Sildenafil is rapidly absorbed. Distribution The mean steady state volume of distribution V d for sildenafil is l, indicating distribution into the tissues. Store in the original package in order to protect from moisture. Date of first authorisation: Company contact details Pfizer Limited. To bookmark a medicine you must sign up and log in.

Sign Up Log In Cancel. And if it does lose it's potency, the worst thing that can happen is that you won't get an erection; that is, it's not life threatening. No BIG thing -- pun intended. By law, all medications in the US have a maximum expiration date of one year after the the drug is dispensed leaves the pharmacy.

Practically, if the pill itself is intact, hasn't changed colors or appearance, and hasn't been exposed to moisture, extreme heat, or direct sunlight, it's likely to be good for four to five years. Ten years in the medical field. Related Questions Do u think excessive use of internet takes u away frm ur family life?

What is shelf life of viagra? Isn't there a shelf life for being in a boy band? Should i use viagra for a better sex life? Can we use viagra for long term may be life time?

Answer Questions She put condom on my penis upside down. What should I do? What is the main cause of erectile dysfunction?

Shelf life for viagra

Renal and urinary disorders. Priapism Agents for the treatment of erectile dysfunction, including sildenafil, should be used with caution in patients with anatomical deformation of the penis such as angulation, cavernosal fibrosis or Peyronie's diseaseor in patients who have conditions which may predispose them to priapism such as sickle cell anaemia, multiple myeloma or leukaemia. Reporting suspected adverse reactions after authorisation of the medicinal product is important. Throat tightness, Nasal oedema, Nasal dryness. In clinical studies, riociguat has been shown to augment the hypotensive effects of PDE5 inhibitors. Subscribe to free Drugs.

May 19,  · Best Answer: If it's turned color, don't use it, but properly stored, Viagra is good for at least five years. (And if it does lose it's potency, the worst thing that can happen is that you won't get an erection; that is, it's not life erectiledysfunctionpills.icu: Resolved. What is the average shelf life of viagra before it expires? Asked 28 Feb by pie wie Updated 1 March Topics viagra. Answer this question. Responses (1) MA. Marvell 1 Mar Viagra shelf life is just the tip of the iceberg when it comes to answering all of the questions that first-time buyers have when taking the plunge on their first shipment of generic Viagra through an .

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