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Viagra Was Originally Developed As A Treatment For

viagra was originally developed as a treatment for

Sildenafil , sold as the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. Common side effects include headaches , heartburn , and flushed skin. Sildenafil acts by blocking phosphodiesterase 5 PDE 5 , an enzyme that promotes breakdown of cGMP , which regulates blood flow in the penis.

Pfizer originally discovered the medication in while looking for a treatment for heart related chest pain. The primary indication of sildenafil is treatment of erectile dysfunction inability to sustain a satisfactory erection to complete intercourse. Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. Tentative evidence suggests that sildenafil may help men who experience antidepressant -induced erectile dysfunction.

While sildenafil improves some markers of disease in people with pulmonary arterial hypertension , it does not appear to affect the risk of death or serious side effects as of [update]. Sildenafil and other PDE5 inhibitors are used off-label to alleviate vasospasm and treat severe ischemia and ulcers in fingers and toes for people with secondary Raynaud's phenomenon ; [12] [13] these drugs have moderate efficacy for reducing the frequency and duration of vasospastic episodes.

Sildenafil has been studied for high-altitude pulmonary edema but its use is currently not recommended for that indication. In clinical trials , the most common adverse effects of sildenafil use included headache , flushing , indigestion , nasal congestion , and impaired vision, including photophobia and blurred vision. In July , the FDA found that sildenafil could lead to vision impairment in rare cases [16] and a number of studies have linked sildenafil use with non-arteritic anterior ischemic optic neuropathy.

Rare but serious adverse effects found through postmarketing surveillance include prolonged erections , severe low blood pressure , myocardial infarction heart attack , ventricular arrhythmias , stroke , increased intraocular pressure , and sudden hearing loss. Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects.

Sildenafil should not be used if sexual activity is inadvisable due to underlying cardiovascular risk factors [21]. Sildenafil's popularity with young adults has increased over the years.

In one study, a mg dose was shown to cause no significant change in erectile quality, but did reduce the postejaculatory refractory time. Unprescribed recreational use of sildenafil and other PDE5 inhibitors is noted as particularly high among users of illegal drugs. Plano, and Diego A. Golombek of Universidad Nacional de Quilmes , Argentina, for their discovery that sildenafil helps treat jet lag recovery in hamsters. Professional athletes have been documented using sildenafil, believing the opening of their blood vessels will enrich their muscles.

In turn, they believe it will enhance their performances. Acetildenafil and other synthetic structural analogs of sildenafil which are PDE5 inhibitors have been found as adulterants in a number of "herbal" aphrodisiac products sold over-the-counter. However, at least one court case has resulted in a product being taken off the market.

The US FDA has banned numerous products claiming to be Eurycoma longifolia that, in fact, contain only analogs of sildenafil. Nitric oxide NO in the corpus cavernosum of the penis binds to guanylate cyclase receptors, which results in increased levels of cGMP, leading to smooth muscle relaxation vasodilation of the intimal cushions of the helicine arteries. This smooth muscle relaxation leads to vasodilation and increased inflow of blood into the spongy tissue of the penis, causing an erection.

Furchgott , Ferid Murad , and Louis Ignarro won the Nobel Prize in Physiology or Medicine in for their independent study of the metabolic pathway of nitric oxide in smooth muscle vasodilation. The molecular structure of sildenafil is similar to that of cGMP and acts as a competitive binding agent of PDE5 in the corpus cavernosum, resulting in more cGMP and better erections.

Other drugs that operate by the same mechanism include tadalafil Cialis and vardenafil Levitra. Sildenafil is broken down in the liver by hepatic metabolism using cytochrome p enzymes, mainly CYP 3A4 major route , but also by CYP2C9 minor route hepatic isoenzymes. The major product of metabolisation by these enzymes is N-desmethylated sildenafil, which is metabolised further. If taken with a high-fat meal, absorption is reduced; the time taken to reach the maximum plasma concentration increases by around one hour, and the maximum concentration itself is decreased by nearly one-third.

There are also mouth spray preparations of sildenafil for faster onset of action. The preparation steps for synthesis of sildenafil are: Sildenafil compound UK, was synthesized by a group of pharmaceutical chemists working at Pfizer's Sandwich, Kent , research facility in England. It was initially studied for use in hypertension high blood pressure and angina pectoris a symptom of ischaemic heart disease. The first clinical trials were conducted in Morriston Hospital in Swansea. Numerous sites on the Internet offer Viagra for sale after an "online consultation", often a simple web questionnaire.

Viagra is also informally known as "vitamin V", "the blue pill", or "blue diamond", as well as various other nicknames. In February , it was announced that Boots , the UK pharmacy chain, would try over-the-counter sales of Viagra in stores in Manchester , England.

Men between the ages of 30 and 65 would be eligible to buy four tablets after a consultation with a pharmacist. While the sale remains subject to a consultation with a pharmacist, the other restrictions from the trial have been removed, allowing customers over the age of 18 to purchase an unlimited number of pills [59] The decision was made, in part, to reduce online sales of counterfeit and potentially dangerous erectile dysfunction treatments.

On 6 May , Pfizer , which manufactures Viagra, told the Associated Press they will begin selling the drug directly to patients on its website. Pfizer's patents on Viagra expired outside the US in ; in the US they were set to expire, but Pfizer settled litigation with each of Mylan and Teva which agreed that both companies could introduce generics in the US on 11 December As of , the U.

Food and Drug Administration has approved 15 drug manufacturers to market generic sildenafil in the United States. Seven of these companies are based in India. This is likely to lead to dramatic price reductions. Counterfeit Viagra, despite generally being cheaper, [67] can contain harmful substances or substances that affect how Viagra works, such as blue printer ink, amphetamines , metronidazole , boric acid , and rat poison. Viagra is one of the world's most counterfeited medicines.

There were 2,, prescriptions for Sildenafil in in England, compared with 1,, in In , Viagra Connect, a particular formulation of Sildenafil marketed by Pfizer, became available for sale without a prescription in the UK, [59] in an attempt to widen availability and reduce demand for counterfeit products. Sildenafil is available as a generic drug in the United States, labelled for pulmonary arterial hypertension. In the United States, Pfizer received two patents for sildenafil: The substance is the same under both trade names.

In , Pfizer filed a patent covering the substance sildenafil and its use to treat cardiovascular diseases. The patent was published in and expired in The patent on Revatio indicated for pulmonary arterial hypertension rather than erectile dysfunction expired in late Generic versions of this low-dose form of sildenafil have been available in the U.

In , Pfizer filed a patent covering the use of sildenafil to treat erectile dysfunction. This patent was published in and will expire in Teva sued to have the latter patent invalidated, but Pfizer prevailed in an August federal district court case.

In Canada , Pfizer's patent 2,, for Revatio sildenafil used to treat pulmonary hypertension was found invalid by the Federal Court in June , on an application by Ratiopharm Inc.

On 8 November , the Supreme Court of Canada ruled that Pfizer's patent 2,, on Viagra was invalid from the beginning because the company did not provide full disclosure in its application.

The decision, Teva Canada Ltd. This, in my view, is the key issue in this appeal. Manufacture and sale of sildenafil citrate drugs known as "generic Viagra" is common in India , where Pfizer's patent claim does not apply. Manufacture and sale of sildenafil citrate drugs is common in China , where Pfizer's patent claim is not widely enforced. Sildenafil was reclassified in New Zealand in so it could be bought over the counter from a pharmacist. It is thought that this reduced sales over the Internet and was safer as men could be referred for medical advice if appropriate.

Egypt approved Viagra for sale in , but soon afterwards allowed local companies to produce generic versions of the drug, citing the interests of poor people who would not be able to afford Pfizer's price.

Pfizer's patent on sildenafil citrate expired in Brazil in From Wikipedia, the free encyclopedia. For other uses, see Viagra disambiguation. B No risk in non-human studies. S4 Prescription only CA: P Pharmacy medicines US: British Journal of Clinical Pharmacology. Division of Pfizer, Inc. Retrieved 5 November Retrieved 1 December Retrieved 21 November Two versions of sildenafil hit the market today".

Retrieved 24 November Centers for Medicare and Medicaid Services. The Cochrane Database of Systematic Reviews 1: The Cochrane Database of Systematic Reviews 5: Annals of the Rheumatic Diseases. PDE-5 inhibitors appear to have significant but moderate efficacy in secondary [Raynaud's phenomenon]. Commonly-used classes of drugs". Cochrane Database of Systematic Reviews. Food and Drug Administration. Archived from the original on 22 October The American Journal of Cardiology.

Journal of the American College of Cardiology. J Am Pharm Assoc Retrieved 15 July

Viagra - A Reliable Impotence Treatment Viagra was originally developed as a potential treatment for angina | Viagra Online News

Viagra was originally developed as a treatment for

Viagra touted as life-saving heart treatment - after scientists find it makes heart muscles LESS stiff. Bing Site Web Enter search term: Download our iPhone app Download our Android app. Today's headlines Most Read Samsung finally unveils its new Galaxy devices: Researchers confirm 10th century skeleton buried in Sweden with the Meet the new Galaxy wearables: Autonomous machines work side-by-side with Facebook set to take on Amazon and Apple with its own virtual assistant it hopes will be smarter than Siri Samsung's latest iPhone killers: Why zebras have stripes: Black and white pattern 'dazzles' blood-sucking flies and makes it harder for them Earth's atmosphere stretches beyond the MOON: Study on observations made in the s reveals outer limits King Arthur's bridge will rise again: Tintagel Castle's legendary lost crossing that vanished centuries ago Experts warn of 'thriving illicit trade' in personal Samsung's folding phone is HERE: Your Google security system could be spying on you!

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Bigger and better in every way: The simplicity of taking an oral tablet for erectile dysfunction has revolutionized treatment. However, PDE5 inhibitors may not work in about 30 percent of men. It is important for men to know that there are other options available for ED. These solutions were used prior to Viagra, and are still available today:. These options may be useful for some; however, for many men they can be complicated, painful, and more expensive. Be sure to talk to your doctor about all options.

Media advertising has dramatically, and sometimes sensationally, increased the awareness of "Low-T" or low blood testosterone also called androgen deficiency. Men with low blood testosterone levels may suffer from a lower sex drive, erectile dysfunction ED , brittle bones osteoporosis , low muscle mass and higher fat accumulation. However, a report from the Testosterone Trials noted that testosterone therapy can raise the risk of heart disease and stroke, and may not be safe is men with low-but-normal testosterone levels and no outward symptoms related to low T.

Testosterone therapy is available by injection, gel, skin patch, spray or lozenge to raise testosterone levels. However, in addition to heart risks, older men who take testosterone replacements may need to have regular prostate cancer screening tests. Plus, testosterone therapy currently carries a boxed warning of potential heart risks, mandated by the FDA.

One more important point: Erectile dysfunction drugs have finally become affordable due to generic availability. However, some men still prefer the brand names. Much of the advertised Viagra on the Internet is counterfeit , and may even contain dangerous and toxic drugs. To help combat the counterfeit market, Pfizer now offers online Viagra prescription orders and home delivery through licensed pharmacies.

Just check out their website at Viagra. In December , generic versions of Viagra became commercially available, which has lowered cost considerably. Know that these prices can vary based on the pharmacy, your location, and if you use an online pharmacy coupon. Another option is to talk to your doctor about using the generic form of Revatio sildenafil , approved for pulmonary hypertension.

It's the same drug that's in Viagra, just at a slight lower dose. Just like Viagra, you'll need a prescription, but the cost savings are significant, too. Viagra has become the victim of Internet fraud due to its rapid success and famous name.

According to Pfizer, 80 percent of the top 22 Internet sites that came up in search results for the phrase "buy Viagra" were selling counterfeit pills. Products sold as "natural" or "herbal" Viagra claim to enhance performance; however, these illegal products have not undergone FDA review or approval. Fraudulent Viagra products contain unknown chemical ingredients that may pose a serious health risk. More than 50 million women experience some type of sexual dysfunction.

Studies looking at Viagra in women have theorized that sildenafil could increase genital blood flow and boost arousal. However, most studies have found a limited beneficial effect of Viagra for women. Lack of sex drive in a woman is a complicated process, often magnified by stress, hormonal changes, or lack of intimacy.

However, medications to help boost libido in women are becoming available. Addyi flibanserin was approved in August to treat low sex drive -- generalized hypoactive sexual desire disorder HSDD in pre-menopausal women. Osphena ospemifene , as well as Intrarosa prasterone are available for vaginal dryness and dyspareunia painful intercourse that can interfere with sex in menopausal women. In May , Imvexxy estradiol vaginal insert was also approved for females who experience painful sexual intercourse.

Other medications used for the treatment of erectile dysfunction, Cialis generic: For most men interested in cost savings, switching to the generic forms may be a good option if they use other brands such as Staxyn vardenafil , an orally disintegrating form of vardenafil, or Stendra avanafil. Generic options for these brands are not yet on the market.

Ask your doctor or pharmacist about switching. If you prefer not to switch to the generic, be sure to check with the manufacturer of the product you use to determine if they have discount programs that might help save you some money.

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Refer to our editorial policy for content sources and attributions. We comply with the HONcode standard for trustworthy health information - verify here. The Unexpected Discovery of Viagra. Which Medications Cause ED?

Medications that may lead to erectile dysfunction include: Just the Basic Facts: What's the Safest Way to Take Viagra? Does Viagra Have Side Effects? Side effects may include: Headache Flushing Heartburn Vision problems Nausea Dizziness Report a sudden hearing or vision loss to your healthcare provider immediately.

Other Options for Erectile Dysfunction. These solutions were used prior to Viagra, and are still available today: Penile self-injection Caverject Transurethral suppositories MUSE Vacuum-assisted erection devices Surgical penile prostheses These options may be useful for some; however, for many men they can be complicated, painful, and more expensive.

What is Low T? These trials were a set of seven year-long clinical trials conducted at 12 sites across the United States.

Viagra was originally developed as a treatment for

FurchgottFerid Muradand Louis Ignarro won the Nobel Prize in Physiology or Medicine in for their independent study of the metabolic pathway of nitric oxide in smooth muscle vasodilation. An erection lasting more then 4 hours priapism is buy generic cialis online 40mg rare event, but if it occurs get emergency treatment. Penile self-injection Caverject Transurethral suppositories MUSE Vacuum-assisted erection devices Surgical penile prostheses These options may be useful for some; however, for many men they can be complicated, painful, and more expensive. Food and Drug Administration. While sildenafil improves some markers of disease in people with pulmonary arterial hypertensionit does not appear to affect the risk of death or serious side effects as of [update]. There are also mouth spray preparations of sildenafil for faster onset of action. Retrieved August 10,

Viagra was originally developed as a treatment for Plavix, cialis was approved 26, used to buy viagra wayne it has been discovered the name for erection. Given the pharmaceutical manufacturing giant pfizer to help you help cialis dipendente viagra compare revatio. Viagra helps ailing hearts to recover in a surprising way - by making them less stiff, scientists have learned. The drug was first developed as a heart disease treatment - it's more well-known use. Viagra was originally developed by US corporation Pfizer to treat cardiac insufficiency. In many patients, however, it led to intense erections. Until then, in order to treat erectile dysfunction, drugs had to be injected directly into the penis' cavernous body.

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